In chronic and sometimes incapacitating pain syndromes—such as irritable bowel syndrome, headaches, low back pain, fibromyalgia, and neuropathic pain—the overlap between anxiety, depression, and pain is particularly evident. For example, symptoms of psychological distress, most commonly anxiety, are present in approximately two-thirds of patients with irritable bowel syndrome who are referred for follow-up care. Conversely, at least one pain-related symptom is reported by about 65% of individuals seeking treatment for depression.

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Pain usually signals an underlying disease or injury that causes tissue inflammation. Because pain is a subjective experience with no single, precise definition, each patient interprets its intensity and quality based on how it affects them in the moment. While medication can be helpful, doctors and pain management teams have many other options for treating pain—both immediately and long-term.

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